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Acertara at the Forefront of Technology Development The National Institutes of Health (NIH) and Vanderbilt University

The Corner Office

Wayne Moore


In addition to the pioneering development work in the field of ultrasound test equipment creation and advanced probe repair, Acertara is well-known in the scientific community for its work in the creation of new technologies for advancing the science of ultrasound for use in new and exciting clinical applications. Over the past several years our R&D team has focused on joint-development projects centered around using ultrasound to create temporary windows in the blood-brain barrier using burst-mode focused ultrasound (FUS) that induces stable microbubble cavitation in the vasculature which in turn temporarily disrupts the blood-brain barrier (BBB) to enable therapeutic agent delivery. Other uses of modified ultrasound transmit sequencing outside the brain include sonoporation, which can modify the permeability of cell membranes using the mechanical force of focused ultrasound to enhance the absorption of the larger molecules associated with various therapeutic drugs and genes, and neuromodulation which has shown significant promise with patients in persistent comas. Indeed, the Venn area between diagnostic ultrasound and therapeutic ultrasound is growing rapidly and will continue to do so as new technologies are explored and introduced.

Vanderbilt University Medical Center and Acertara Labs have this month been awarded a multi-year grant from the NIH to develop and commercialize a novel ultrasound device that will be used for Transcranial Ultrasound Stimulation (TUS) using acoustic power levels that will allow more effective levels of energy to reach deeper into the brain. As we progress with this development effort, I will provide updates through our newsletter.

Until Next Month,

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October 31, 2023 Newsletter